[vc_row][vc_column][ultimate_spacer height=”35″ height_on_tabs=”25″ height_on_tabs_portrait=”25″ height_on_mob_landscape=”25″ height_on_mob=”25″][vc_custom_heading text=”NATURE NEUROSCIENCE” font_container=”tag:p|text_align:left|line_height:1.3em” google_fonts=”font_family:Muli%3A300%2C300italic%2Cregular%2Citalic|font_style:400%20regular%3A400%3Anormal” css_animation=”slideInLeft”][ultimate_spacer height=”10″ height_on_tabs=”10″ height_on_tabs_portrait=”10″ height_on_mob_landscape=”10″ height_on_mob=”10″][vc_custom_heading text=”Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish” font_container=”tag:h3|text_align:left|line_height:1.3em” google_fonts=”font_family:Muli%3A300%2C300italic%2Cregular%2Citalic|font_style:400%20regular%3A400%3Anormal” css_animation=”slideInLeft”][ultimate_spacer height=”10″ height_on_tabs=”10″ height_on_tabs_portrait=”10″ height_on_mob_landscape=”10″ height_on_mob=”10″][vc_column_text]Neil I Bower, Katarzyna Koltowska, Cathy Pichol-Thievend, Isaac Virshup, Scott Paterson, Anne K Lagendijk, Weili Wang, Benjamin W Lindsey, Stephen J Bent, Sungmin Baek, Maria Rondon-Galeano, Daniel G Hurley, Naoki Mochizuki, Cas Simons, Mathias Francois, Christine A Wells , Jan Kaslin & Benjamin M Hogan [/vc_column_text][ultimate_spacer height=”25″ height_on_tabs=”25″ height_on_tabs_portrait=”25″ height_on_mob_landscape=”25″ height_on_mob=”25″][vc_column_text]Mural cells of the vertebrate brain maintain vascular integrity and function, play roles in stroke and are involved in maintenance of neural stem cells. However, the origins, diversity and roles of mural cells remain to be fully understood. Using transgenic zebrafish, we identified a population of isolated mural lymphatic endothelial cells surrounding meningeal blood vessels. These meningeal mural lymphatic endothelial cells (muLECs) express lymphatic endothelial cell markers and form by sprouting from blood vessels. In larvae, muLECs develop from a lymphatic endothelial loop in the midbrain into a dispersed, nonlumenized mural lineage. muLEC development requires normal signaling through the Vegfc–Vegfd–Ccbe1–Vegfr3 pathway. Mature muLECs produce vascular growth factors and accumulate low-density lipoproteins from the bloodstream. We find that muLECs are essential for normal meningeal vascularization. Together, these data identify an unexpected lymphatic lineage and developmental mechanism necessary for establishing normal meningeal blood vasculature.[/vc_column_text][ultimate_spacer height=”25″ height_on_tabs=”25″ height_on_tabs_portrait=”25″ height_on_mob_landscape=”25″ height_on_mob=”25″][vc_column_text]READ FULL PUBLICATION
Bower et al., 2017 (1.3 MB)
Bower et al., 2017 supplementary (2 MB)[/vc_column_text][ultimate_spacer height=”25″ height_on_tabs=”25″ height_on_tabs_portrait=”25″ height_on_mob_landscape=”25″ height_on_mob=”25″][vc_btn title=”back to publications” color=”orange” i_icon_fontawesome=”fa fa-bookmark-o” add_icon=”true” link=”url:http%3A%2F%2Flindseylab.ca%2Fpublications%2F|title:PUBLICATIONS%202||”][ultimate_spacer height=”25″ height_on_tabs=”25″ height_on_tabs_portrait=”25″ height_on_mob_landscape=”25″ height_on_mob=”25″][/vc_column][/vc_row]